Bactrim/Septra

SULFAMETHOXAZOLE-TRIMETHOPRIM (SMX)/COTRIMOXAZOLE (CTX)

AND 

PHARMACOGENETIC STUDY RESULTS: 

POSITIVE ASSOCIATION BETWEEN 

HLA-B*38, HLA-B*15:02, HLA-B*13:01, HLA-A*11:01, HLA-C*08:01 

AND SJS/TEN AND SCAR FROM SMX-TMP AND CTX

HLA-B*38 and SMX-TMP/CTX

European populations                                                                                                                                                                                      

• Lonjou, et al. A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenetics and Genomics 2008, 18:99–107.   https://sjs-ten.org/Lonjou-et-al 

Asian populations (Chinese, Thai, and Malaysian populations)                                                                                                            

• Wang, et al. Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians. J Allergy Clin Immunol 2021; 147:1402-12.   https://sjs-ten.org/Wang-et-al
• Wu, et al. Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole–Induced Severe Cutaneous Adverse Reactions A Systematic Review and Meta-Analysis. JAMA Dermatol. 2024;160(5):525-534.   https://sjs-ten.org/Wu-et-al

HLA-B*15:02 and SMX-TMP/CTX                                                                                                                                                                 

Thai Population                                                                                                                                                                                                 

• Kongpan, et al.  Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions. Pharmacogenetics and Genomics, 2015; 25(8):402–411.   https://sjs-ten.org/Kongpan-et-al
• Sukasem, et al. Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes. Clinical Pharmacology and Therapeutics 2020, 108 (5):1078-1089.   https://sjs-ten.org/Sukkasem-2020-et-al
• Nakkam, et al. Associations of HLA and drug-metabolizing enzyme genes in cotrimoxazole-induced severe cutaneous adverse reactions. Drug Metabolism and Pharmacokinetics 47 (2022) 100480.   https://sjs-ten.org/Nakkam-et-al

Asian populations                                                                                                                                                                                               

• Wu, et al. Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole–Induced Severe Cutaneous Adverse Reactions A Systematic Review and Meta-Analysis. JAMA Dermatol. 2024;160(5):525-534.   https://sjs-ten.org/Wu-et-al

HLA-B*13:01 and SMX-TMP/CTX                                                                                                                                                                  

Thai population                                                                                                                                                                                                    

• Sukasem, et al. Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes. Clinical Pharmacology and Therapeutics 2020, 108 (5):1078-1089.   https://sjs-ten.org/Sukkasem-2020-et-al

• Jantararoungtong, et al. Genotyping HLA alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art. Expert Opinion on Drug Metabolism & Toxicology, 2021;17(9): 1049–1064.    https://sjs-ten.org/Jantararoungtong-et-al
• Nakkam, et al. Associations of HLA and drug-metabolizing enzyme genes in cotrimoxazole-induced severe cutaneous adverse reactions. Drug Metabolism and Pharmacokinetics 47 (2022) 100480.    https://sjs-ten.org/Nakkam-et-al
•  Pinyopornpanish, et al.  The role of HLA B*13:01 and HLA B*15:02 for predicting sulfonamide/trimethoprim-induced Severe Cutaneous Adverse Reactions (SCAR). J Allergy Clin Immunol 2023; Abstract No. 354.   https://sjs-ten.org/Pinyopornpanish-et-al

Chinese, Thai, and Malaysian populations                                                                                                                                        

• Wang, et al. Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians. J Allergy Clin Immunol 2021; 147:1402-12.    https://sjs-ten.org/Wang-et-al
• Wu, et al. Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole–Induced Severe Cutaneous Adverse Reactions A Systematic Review and Meta-Analysis. JAMA Dermatol. 2024;160(5):525-534.    https://sjs-ten.org/Wu-et-al

HLA-C*08:01 and SMX-TMP/CTX and HIV/AIDS patients

Thai population                                                                                                                                                                                           

• Nakkam, et al. Associations of HLA and drug-metabolizing enzyme genes in cotrimoxazole-induced severe cutaneous adverse reactions. Drug Metabolism and Pharmacokinetics 47 (2022) 100480.     https://sjs-ten.org/Nakkam-et-al

HLA-A*11:01 and SMX-TMP/CTX

Japanese population                                                                                                                                                                                   

• Nakamura, et al. Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients. Journal of Investigative Dermatology (2020) 140, 1659e1662.   https://sjs-ten.org/Nakamura-et-al

Asian populations (Malaysia, Taiwan, Thailand)                                                                                                                                     

• Wu, et al. Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole–Induced Severe Cutaneous Adverse Reactions a Systematic Review and Meta-Analysis. JAMA Dermatol. 2024;160(5):525-534.    https://sjs-ten.org/Wu-et-al