LAMOTRIGINE AND PHARMACOGENETIC STUDY RESULTS: 

POSITIVE ASSOCIATION BETWEEN HLA-A and HLA-B ALLELES

AND SJS/TEN AND SCAR FROM LAMOTRIGINE

HLA-B*38 and European and U.S. Caucasians, Spaniards and Iranian populations     

European populations                                                                                                                                                                        

• Lonjou, et al.  A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis to five high-risk drugs. Pharmacogenetics and Genomics 2008, 18:99–107.  https://sjs-ten.org/Lonjou-et-al
• Ramirez, et al. Significant HLA class I type associations with aromatic antiepileptic-drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population. Pharmacological Research 115 2017 168–178. https://sjs-ten.org/Ramirez-et-al-2017
• Rashid, et al. Role of human leukocyte antigen in anti-epileptic drugs-induced Stevens–Johnson Syndrome/toxic epidermal necrolysis: A meta-analysis. European Journal of Epilepsy 2022, 102: 36–50.  https://sjs-ten.org/Rashid-et-al

Iranian Population                                                                                                                                                                                  

•  Mortazavi, et al. Association between human leukocyte antigens and cutaneous adverse drug reactions to antiepileptics and antibiotics in the Iranian population. Dermatologic Therapy, Feb. 2022; 35(5), e15393.    https://sjs-ten.org/Mortazavi-et-al

U.S. population                                                                                                                                                                                       

• Ashraf, et al. HLA Class I Alleles are strongly associated with lamotrigine-induced SJS/TEN in a U.S. population. Investigative Ophthalmology & Visual Science, June 2024, 65:  4234.  https://sjs-ten.org/Ashraf-et-al

HLA-B*15:02 and Asian and Iranian populations

Chinese populations                                                                                                                                                                                 

• Hung, et al. Common Risk Allele in Aromatic Antiepileptic-Drug SJS and TEN in Han Chinese.  Pharmacogenomics 2010, 11(3):349-356.  https://sjs-ten.org/Hung-et-al
• Cheung, et al. HLA-B Alleles with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia, 2013, 54(7):1307–1314.   https://sjs-ten.org/Cheung-et-al
• Kwan, et al. Association between HLA–B*15:02 allele and antiepileptic drug–induced severe cutaneous reactions in Hong Kong Chinese: a population-based study.     Hong Kong Med  J 2014;20(Suppl 7): S16-8.     https://sjs-ten.org/Kwan-et-al                                                                                                                
• Zeng, et al. Association of HLA-B*1502 allele with lamotrigine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta-analysis. International Journal of Dermatology 2015, 54, 488–493.  https://sjs-ten.org/Zeng-et-al
• Li, et al. HLA-B*1502 Increases the Risk of Phenytoin or Lamotrigine Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Evidence from a Meta-analysis of Nine Case-control Studies. Drug Res 2015; 65: 107–111.   https://sjs-ten.org/Li-et-al

 See More Articles About Other Alleles 

• Deng, et al. Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in Asian populations: A meta-analysis. European Journal of Epilepsy 2018; 60: 163–171.  https://sjs-ten.org/Deng-et-al

Thailand populations                                                                                                                                                                                

• Koomdee, et al. HLA-B*15:02 genotype associated with hypersensitivity syndrome to lamotrigine in Thai population. Clinical and Translational Allergy 2014, 4(Suppl. 3): 121. https://sjs-ten.org/Koomdee-et-al
• Koomdee, et al. Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population. Front Pharmacol. 2017 Nov 29; 8:879.  https://sjs-ten.org/Koomdee-et-al-2017
• Sukasem, et al. Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis. The Pharmacogenomics Journal (2021) 21:682–690. https://sjs-ten.org/Sukasem-et-al

Korean populations                                                                                                                                                                               

• Das, et al.    Genetic Predisposition for the Development of Lamotrigine-Induced Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: A Systematic Review and Meta-Analysis. Personalized Medicine 2023, 20(2): 201-213. https://sjs-ten.org/Das-et-al

Iranian population                                                                                                                                                                                 

• Sabourirad, et al. Investigating the association of Lamotrigine and Phenytoin induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population. Experimental Dermatology. 2021; 30:284–287.  https://sjs-ten.org/Sabourirad-et-al

Multiple Asian populations                                                                                                                                                                     

• Rashid, et al.  Role of human leukocyte antigen in anti-epileptic drugs-induced Stevens–Johnson Syndrome/toxic epidermal necrolysis: A meta-analysis. European Journal of Epilepsy 2022, 102: 36–50.   https://sjs-ten.org/Rashid-et-al
• Das, et al. Genetic Predisposition for the Development of Lamotrigine-Induced Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: a Systematic Review and Meta-Analysis. Personalized Medicine 2023, 20(2): 201-213.   https://sjs-ten.org/Das-et-al
• Tham, et al.   Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis.   Pharmacogenetics and Genomics 2024, 34(5): 154-165.  https://sjs-ten.org/Tham-et-al

HLA-A*24:02 and Chinese, Korean and Thai populations                                                                                                                

• Moon, et al. The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population. Epilepsia 2015, 56(10):e161–e167.  https://sjs-ten.org/Moon-et-al
• Deng, et al. Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in Asian populations: A meta-analysis. European Journal of Epilepsy 2018; 60: 163–171.   https://sjs-ten.org/Deng-et-al
• Rashid, et al. Role of human leukocyte antigen in anti-epileptic drugs-induced Stevens–Johnson Syndrome/toxic epidermal necrolysis: A meta-analysis. European Journal of Epilepsy 2022, 102: 36–50.    https://sjs-ten.org/Rashid-et-al

 See More Articles About Other Alleles 

• Tham, et al. Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens–Johnson syndrome/toxic epidermal necrolysis. Pharmacogenetics and Genomics 2024, 34(5): 154-165.  https://sjs-ten.org/Tham-et-al

HLA-A*24:02 and Multiple populations from Japan, Malaysia, Mexico, Norway, THAILAND and China                              

• Shi, et al. HLA-A*24:02 as a common risk factor for antiepileptic drug–induced cutaneous adverse reactions. https://sjs-ten.org/Shi-et-al
• Li, et al. HLA-A∗24:02 associated with lamotrigine-induced cutaneous adverse drug reactions A systematic review and meta-analysis. Medicine 2020;99:52(e23929).  https://sjs-ten.org/Li-w-et-al
• Rashid, et al. Role of human leukocyte antigen in anti-epileptic drugs-induced Stevens–Johnson Syndrome/toxic epidermal necrolysis: A meta-analysis. European Journal of Epilepsy 2022, 102: 36–50.  https://sjs-ten.org/Rashid-et-al

HLA-A*44:03 and HLA-A*31:01 and Korean populations                                                                                                               

• Park, et al. Clinical features of and genetic predisposition to drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients—investigating the relation between the HLA-B*4403 allele and lamotrigine. Eur J Clin Pharmacol (2015) 71:35–41.   https://sjs-ten.org/Park-et-al
• Park, et al. HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs. Yonsei Med J 2016 Jan;57(1):118-126.  https://sjs-ten.org/Park-et-al-2016
• Kim, et al. HLA-A*31:01 and lamotrigine-induced severe cutaneous adverse drug reactions in a Korean population. Annals Allergy, Asthma & Immunology, May 2017, 118 (5): 629-630.   https://sjs-ten.org/Kim-et-al

HLA-B*13:01 and North Indian population                                                                                                                                        

• Ihtisham, et al. Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population. European Journal of Epilepsy 2019, 66: 99–103.   https://sjs-ten.org/Ihtisham-et-al

HLA-A*02:01, HLA-B*35:01, HLA-C*04 and Mexican Population                                                                                                 

• Fricke-Galindo, et al. HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients. Pharmacogenomics (2014) 15(15), 1881–1891.   https://sjs-ten.org/Fricke-Galindo-et-al