The management of SJS Stevens Johnson Syndrome  is interprofessional. A number of specialists are usually involved in the care of these patients, including a dermatologist, intensivist, ophthalmologist, pulmonologist, nephrologist, plastic surgeon, and gastroenterologist, functioning as an interprofessional team. 

The acute care of Stevens Johnson Syndrome patients are provided wound care. Critical care nurses provide much of the hands-on care. The pharmacist must also closely assess the medications that the patient is receiving to prevent exacerbation of the disorder or determine if any of the patient's medications could be the trigger for the condition.

Even after treatment, Stevens Johnson Syndrome patients may have severe cosmetic deficits and may require mental health counseling. If the lesions occur across joints, the patient may benefit from physical therapy to restore function and muscle strength.  Stevens Johnson Syndrome patient has to be educated on the use of ocular lubricants because of the sicca-like syndrome.